Argireline¶

Identification¶

Property	Value
CAS Number	616204-22-9
Molecular Formula	C₃₄H₆₀N₁₄O₁₂S
Molecular Weight	~889.0 Da
Sequence	Ac-Glu-Glu-Met-Gln-Arg-Arg-NH₂
Amino Acid Count	6 (N-terminal acetyl, C-terminal amide)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile water; cosmetic formulation-compatible
Storage	2–8°C, desiccated, protect from light

Category: Cosmetic & Skin

Catalog SKU: PSH-ARGIR-10MG

Research Background¶

Argireline (Acetyl Hexapeptide-8) is the most extensively studied anti-wrinkle peptide in cosmetic research. It functions as a competitive inhibitor of SNARE complex formation — the protein machinery that mediates synaptic vesicle docking and neurotransmitter release. By mimicking the N-terminal domain of SNAP-25, Argireline prevents formation of the ternary SNARE complex, reducing acetylcholine release at the neuromuscular junction. This produces a topical 'botulinum-mimetic' effect in research models.

Key Mechanisms¶

Mechanism	Details
SNARE Complex Disruption	Mimics SNAP-25 N-terminal → competes for ternary SNARE complex formation
Vesicle Docking Inhibition	Prevents stable vesicle-membrane association → reduced exocytosis
ACh Release Suppression	Decreased quantal acetylcholine release at neuromuscular junction

Research Focus Areas¶

Expression Lines¶

SNARE complex inhibition → reduced vesicle docking → decreased ACh release

Forehead Wrinkles¶

Frontalis muscle relaxation in topical formulation models

Crow's Feet¶

Periorbital wrinkle severity reduction in split-face studies

Topical Botulinum-Mimetic¶

Non-invasive neurotransmitter modulation for cosmetic research

Available Configurations¶

Configuration	Content	Best For
Standard Kit	10 mg × 10 vials	Anti-wrinkle formulation research; evaluation
Bulk Kit	50 mg × 10 vials	Product development; pilot production
Custom	Custom mg × custom vials	OEM; private-label cosmetics

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~889.0 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: How does Argireline work in anti-wrinkle research?¶

Argireline mimics the N-terminal domain of SNAP-25, competitively inhibiting formation of the SNARE complex. Without a functional SNARE complex, synaptic vesicles cannot dock — ACh release is reduced, muscle fibers relax, and expression lines diminish in topical models.

Q2: What distinguishes Argireline from Snap-8?¶

Both target SNARE-mediated neurotransmitter release. Argireline prevents initial formation of the ternary SNARE complex. Snap-8 specifically targets the SNAP-25 binding site within an already-assembling complex. Argireline is the most-studied peptide in this class.

Q3: Is Argireline considered a 'topical Botox'?¶

In research terminology, Argireline is described as a 'topical botulinum-mimetic' because both reduce ACh release at the NMJ. However, mechanisms differ: botulinum toxin proteolytically cleaves SNARE proteins, while Argireline competitively inhibits SNARE assembly. Non-invasive topical delivery is the key distinction.

Q4: What is the optimal pH for Argireline in formulations?¶

Stable at pH 5.0–7.0. N-terminal acetylation and C-terminal amidation protect against exopeptidase degradation. Avoid strongly acidic (pH < 4) or alkaline (pH > 8) conditions.

Q5: What documentation is provided with Argireline?¶

Batch-specific COA: HPLC purity (≥99%), ESI-MS identity, peptide content by amino acid analysis. Commercial invoice and packing list included. Full analytical package for bulk orders.

Key Research References¶

Reference	PMID	Key Finding
Blanes-Mira C et al. "A synthetic hexapeptide (Argireline) with antiwrinkle activity." Int J Cosmet Sci. 2002;24(5):303–310.	18498523	Argireline inhibits SNARE complex formation by mimicking SNAP-25 N-terminal domain; reduces ACh release in a topical botulinum-mimetic mechanism
Lupo MP & Cole AL. "Cosmeceutical peptides." Dermatol Ther. 2007;20(5):343–349.	18045359	Comprehensive review of Argireline as the prototypical neurotransmitter-inhibiting cosmetic peptide for anti-wrinkle applications

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	Standard peptide stability; 24 months at 2–8°C in desiccated environment, protect from light
Neutral pH (5.0–7.0)	Stable; N-terminal acetylation and C-terminal amidation protect against exopeptidase degradation
Acidic pH (<4.0)	Avoid strongly acidic conditions; Met³ residue susceptible to oxidation
Alkaline pH (>8.0)	Risk of Met³ oxidation and peptide bond hydrolysis; avoid alkaline buffers
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C for extended use. Avoid repeated freeze-thaw

Source & Purchase¶

For research-grade ARGIRELINE and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

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