CJC-1295 (DAC)¶

Identification¶

Property	Value
CAS Number	863288-34-0
Molecular Formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight	~3,649.2 Da
Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH₂
Amino Acid Count	30 (C-terminal DAC linker)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Soluble in sterile or bacteriostatic water
Storage	2–8°C, desiccated, protect from light

Category: Muscle Growth

Catalog SKU: PSH-CJC1295D-2MG

Research Background¶

CJC-1295 is a synthetic analogue of Growth Hormone-Releasing Hormone (GHRH) engineered with four amino acid substitutions that enhance receptor binding and proteolytic stability. The defining feature of the DAC (Drug Affinity Complex) variant is a maleimidopropionyl linker on the C-terminal lysine that covalently binds to Cys³⁴ of serum albumin — extending circulating half-life from ~7 minutes to ~8 days. For research protocols requiring chronic GH/IGF-1 axis activation, CJC-1295 with DAC is the tool of choice.

Key Mechanisms¶

Mechanism	Details
GHRH-R Agonism	Full GHRH receptor activation → cAMP → GH synthesis and release from pituitary
DAC-Albumin Conjugation	Maleimidopropionyl linker covalently binds Cys³⁴ of serum albumin → half-life extended from ~7 min to ~8 days
IGF-1 Cascade	Sustained GH → hepatic IGF-1 production → systemic anabolic signaling

Research Focus Areas¶

GH Secretion¶

Sustained GHRH receptor activation → prolonged GH elevation

Body Composition¶

Lean mass preservation; fat mass reduction models

Muscle Protein Synthesis¶

GH/IGF-1 axis-mediated anabolic signaling

Recovery Research¶

Post-exercise GH pulse augmentation in trained models

Available Configurations¶

Configuration	Content	Best For
Standard Kit	2 mg × 10 vials	GH pulse research; evaluation
Bulk Kit	5 mg × 10 vials	Chronic GH axis studies; repeat orders
Custom	Custom mg × custom vials	OEM; private-label; protocol-specific

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~3,649.2 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: What is the DAC in CJC-1295?¶

DAC stands for Drug Affinity Complex — a maleimidopropionyl linker that covalently binds to Cys³⁴ of serum albumin. This conjugation extends half-life from minutes to ~8 days by preventing renal clearance and enzymatic degradation.

Q2: Difference between CJC-1295 with DAC and without DAC?¶

With DAC: ~8 day half-life → sustained GHRH activation → chronic GH/IGF-1. Without DAC: ~30 min half-life → discrete GH pulse → mimics endogenous pulsatile secretion. Choice depends on research objective.

Q3: Why pair CJC-1295 with Ipamorelin?¶

CJC-1295 amplifies the GHRH signal (the 'on' switch). Ipamorelin suppresses somatostatin tone (the 'off' switch). Together they produce a larger net GH pulse than either alone — well-characterized synergism.

Q4: How should CJC-1295 (DAC) be stored?¶

Lyophilized: 2–8°C, desiccated, 24-month stability. After reconstitution, store at 2–8°C. The DAC-albumin conjugate forms spontaneously — this is expected and part of the molecule's designed mechanism.

Q5: What configurations are available?¶

Standard: 2mg × 10 vials. Bulk: 5mg × 10 vials. Custom mg/vial for OEM/private-label. CJC-1295 (no DAC) also available as a separate SKU for pulsatile GH protocols.

Key Research References¶

Reference	PMID	Key Finding
Teichman SL et al. "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults." J Clin Endocrinol Metab. 2006;91(3):799–805.	16352683	CJC-1295 with DAC demonstrated sustained GH and IGF-1 elevation with ~8-day half-life via covalent albumin conjugation
Ionescu M & Frohman LA. "Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog." J Clin Endocrinol Metab. 2006;91(12):4792–4797.	17018654	CJC-1295 pharmacokinetic characterization: DAC variant enables sustained pituitary stimulation while maintaining pulsatile GH secretion pattern

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	24 months at 2–8°C in desiccated environment, protect from light
DAC Linker Stability	The maleimidopropionyl linker is reactive with free thiols; keep away from reducing agents (DTT, β-mercaptoethanol) which may cleave the DAC-albumin bond
Neutral pH (6.0–7.5)	Stable; recommended for reconstitution
Albumin Conjugation	The DAC linker covalently binds Cys³⁴ of serum albumin spontaneously in solution — this is the designed mechanism, not degradation
Reconstituted Solution	24 h at 2–8°C. The DAC-albumin conjugate forms in solution — expect mass shift on analytical characterization. Avoid repeated freeze-thaw

Source & Purchase¶

For research-grade CJC 1295 DAC and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

Browse CJC 1295 DAC & Related Products →

Product	Link
CJC-1295 (no DAC)	cjc-1295-no-dac.md — Short-acting GHRH analogue for pulsatile GH
Ipamorelin	ipamorelin.md — Selective GHS-R1a agonist
GHRP-2	ghrp-2.md — Potent ghrelin receptor agonist
HGH (Somatropin)	hgh.md — 191-aa human growth hormone