Matrixyl¶

Identification¶

Property	Value
CAS Number	214047-00-4
Molecular Formula	C₃₉H₇₅N₇O₁₀
Molecular Weight	~803.9 Da
Sequence	Palmitoyl-Lys-Thr-Thr-Lys-Ser-OH
Amino Acid Count	5 (N-terminal palmitoyl)
Appearance	White to off-white lyophilized powder
Purity Standard	≥99% by HPLC
Solubility	Lipid-soluble; limited aqueous solubility
Storage	2–8°C, desiccated, protect from light

Category: Cosmetic & Skin

Catalog SKU: PSH-MATRX-10MG

Research Background¶

Matrixyl (Palmitoyl Pentapeptide-4) is a lipopeptide designed around the concept of 'matrikine' signaling — using small peptide fragments of extracellular matrix proteins to stimulate the skin's own repair mechanisms. It consists of the pentapeptide Lys-Thr-Thr-Lys-Ser conjugated to a palmitic acid (C16) chain for enhanced skin penetration. Unlike neurotransmitter-targeting peptides (Argireline, Snap-8), Matrixyl addresses expression lines from the structural side — rebuilding dermal matrix components rather than inhibiting muscle contraction.

Key Mechanisms¶

Mechanism	Details
Matrikine Signaling	Collagen fragment mimetic → activates fibroblast ECM synthesis programs
TGF-β Pathway	Stimulates TGF-β → procollagen I/III transcription in dermal fibroblasts
Palmitoyl Anchoring	C16 palmitoyl chain → enhanced stratum corneum partitioning and dermal delivery

Research Focus Areas¶

Collagen Synthesis¶

Procollagen I and III upregulation in dermal fibroblast models

ECM Remodeling¶

Fibronectin and elastin production stimulation

Wrinkle Reduction¶

Dermal matrix regeneration in photoaged skin models

Skin Firmness¶

Increased dermal density and elasticity in clinical research

Available Configurations¶

Configuration	Content	Best For
Standard Kit	10 mg × 10 vials	ECM research; formulation evaluation
Bulk Kit	50 mg × 10 vials	Product development; pilot batches
Custom	Custom mg × custom vials	OEM; private-label cosmetics

Tiered Wholesale Pricing¶

Volume	Discount	For
1 kit	List price	Evaluation; competitive analysis
5+ kits	10% off	Initial portfolio expansion
20+ kits	20% off	Mid-size distributors
50+ kits	30% off	Regional distributors

Quality Specifications¶

Parameter	Method	Criterion
Purity	HPLC at 214 nm, C18 column	≥99.0% peak area
Identity (MW)	ESI-MS	~803.9 ± 1.0 Da
Appearance	Visual inspection	White to off-white powder
Peptide Content	Amino acid analysis	≥80% net peptide
Residual Moisture	Karl Fischer	≤3%

Frequently Asked Questions¶

Q1: How does Matrixyl differ from other cosmetic peptides?¶

Matrixyl targets the structural extracellular matrix (collagen, elastin, fibronectin synthesis) rather than neuromuscular signaling. While Argireline/Snap-8 reduce lines by inhibiting contraction, Matrixyl rebuilds dermal matrix components through matrikine signaling.

Q2: What is the purpose of the palmitoyl group?¶

N-terminal palmitoyl (C16) dramatically enhances stratum corneum penetration by partitioning into the lipid-rich intercellular matrix, and anchors the peptide at the cell membrane, prolonging fibroblast receptor interaction. Without it, dermal delivery would be negligible.

Q3: What does 'matrikine' mean?¶

Matrikines are peptide fragments released during ECM degradation that signal cells to initiate repair. Matrixyl mimics this by presenting a collagen-derived peptide sequence to fibroblasts — 'tricking' cells into believing ECM damage has occurred, triggering repair.

Q4: Is Matrixyl compatible with other cosmetic peptides?¶

Yes. Matrixyl's ECM-building mechanism is complementary to neurotransmitter-targeting peptides (Argireline, Snap-8) and copper peptides (GHK-Cu). Multi-peptide formulations combining matrikine + neurotransmitter inhibitor + carrier peptide are common research strategies.

Q5: What purity is Matrixyl supplied at?¶

≥99% by HPLC at 214 nm. Palmitoylation efficiency (>98%) verified by HPLC with ELSD detection. Batch-specific COA included.

Key Research References¶

Reference	PMID	Key Finding
Lintner K & Peschard O. "Biologically active peptides: from a laboratory bench curiosity to a functional skin care product." Int J Cosmet Sci. 2000;22(3):207–218.	18503476	Matrixyl (palmitoyl pentapeptide-4) design concept: matrikine signaling via collagen fragment mimetic; palmitoyl anchor for stratum corneum penetration
Robinson LR et al. "Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin." Int J Cosmet Sci. 2005;27(3):155–160.	18492182	Clinical study: topical Matrixyl reduced wrinkle depth and improved skin firmness through procollagen I/III upregulation in photoaged skin

Stability & Storage¶

Condition	Degradation Profile
Lyophilized Storage	Standard peptide stability; 24 months at 2–8°C in desiccated environment, protect from light
Palmitoyl Stability	N-terminal palmitoyl (C16) enhances structural stability and skin penetration; monitor for hydrolysis of palmitoyl-peptide bond
Neutral pH (5.0–7.0)	Stable; recommended for reconstitution and formulation. Palmitoyl group imparts limited aqueous solubility — use co-solvents in formulation
Reconstituted Solution	24 h at 2–8°C; aliquot and freeze at −20°C for extended use. Expect limited aqueous solubility due to lipophilic C16 chain

Source & Purchase¶

For research-grade MATRIXYL and related compounds in this category, visit the PeptideSourceHub category page for bulk pricing and available specifications.

Browse MATRIXYL & Related Products →

Product	Link
GHK-Cu (Copper Tripeptide)	ghk-cu.md — Copper peptide for collagen synthesis & wound healing
Argireline (Acetyl Hexapeptide-8)	argireline.md — SNARE complex inhibitor
Leuphasyl (Pentapeptide-18)	leuphasyl.md — δ-opioid receptor agonist
Snap-8 (Acetyl Octapeptide-3)	snap-8.md — SNAP-25 competition peptide